Luke A . J . O ' Neill and Signaling TMED 1 Is Involved in Interleukin - 33 The GOLD Domain - containing Protein
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The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling.
The proinflammatory danger signal IL-33, which is released from damaged or dying cells, achieves its effects via the IL-1R family member ST2L. The detection of IL-33 by ST2L initiates downstream signaling pathways that result in the activation of MAPKs and NF-κB. Here, we show that TMED1 associates with ST2L. Using a series of mutation and deletion constructs, we demonstrate that this interacti...
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تاریخ انتشار 2013